Marcela Arango Ospina


Design and development of Ag-doped mesoporous bioactive glass based scaffolds derived from natural marine sponges


Investigator: Marcela Arango Ospina (Master student) Marcela Arango Ospina


Supervisors: Francesca Ciraldo, Prof. Dr.-Ing. habil. Aldo R. Boccaccini

The objective of this research project is to develop and characterize bioactive glass based scaffolds (45S5 BG composition) with enhanced mechanical properties and antibacterial capability. The scaffolds will be prepared via the foam replica technique using natural marine sponges as sacrificial templates [1,2]. Integration of a mesoporous glass doped with antibacterial ions will enhance the antibacterial properties of the system [3]. The scaffolds will be characterized in terms of morphology, mechanical stability and chemical composition. Additionally, bioactivity studies, ion release analysis and antibacterial tests will be carried out.

[1] Chen, Q. Z., Thompson, I. D., & Boccaccini, A. R. (2006). 45S5 Bioglass®-derived glass–ceramic scaffolds for bone tissue engineering. Biomaterials, 27(11), 2414-2425.

[2] Boccardi, E., Philippart, A., Juhasz-Bortuzzo, J. A., Novajra, G., Vitale-Brovarone, C., & Boccaccini, A. R. (2015). Characterisation of Bioglass based foams developed via replication of natural marine sponges. Advances in Applied Ceramics, 114(sup1), S56-S62.

[3] Mouriño, V., Cattalini, J. P., & Boccaccini, A. R. (2012). Metallic ions as therapeutic agents in tissue engineering scaffolds: an overview of their biological applications and strategies for new developments. Journal of the Royal Society Interface, 9(68), 401-419.