Thomas Schuffenhauer

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Additive manufacturing of hydrogel-composite multilayers

 

Investigator: Thomas Schuffenhauer (Master Student) Thomas Schuffenhauer

 

Betreuer: Dr.-Ing. Rainer Detsch, Prof. Dr.-Ing. habil. Aldo R. Boccaccini


Additive manufacturing techniques enable the generation of complex three-dimensional shapes as well as the defined layer-by-layer deposition of different materials or combinations of materials. In this context, the use of hydrogels leads to certain challenges, since they generally possess poor mechanical integrity [1]. Alginate hydrogels have been widely used for biomedical applications such as drug delivery, wound healing and tissue engineering. Alginates are among the most extensively studied materials in the field of bioplotting due to a number of desirable properties such as their natural occurrence, high biocompatibility, printability, and their gel formation ability under mild conditions. Bioactive glasses (BGs) such as 45S5 Bioglass® have been proposed to fabricate composite layers or coatings [2] to support the regeneration of defective bone tissue since BGs possess high osteoconductivity and osteoinductivity. This project aims at the development of a layered scaffold system consisting of hydrogel and composite layers, containing bioactive glass, mimicking the highly complex structure of interface tissues.

[1] T. Zehnder, T. Freund, M. Demir, R. Detsch and A. R. Boccaccini, Materials 2016, 9(11), 887.

[2] Q. Chen, L. Cordero-Arias, J. A. Roether, S. Cabanas-Polo, S. Virtanen and A. R. Boccaccini, Surf. Coatings Technol., 2013, 233, 49–56.