Metallic ion doped mesoporous bioactive glasses: processing and characterisation


Investigator: Yuqian Fan (Master Studentin) Yuqian Fan


Betreuer: Dr.-Ing. Preethi Balasubramanian, Prof. Dr.-Ing. habil. Aldo R. Boccaccini

Bioactive glasses are attractive material for bone tissue and regeneration owing to their excellent osteoconductivity and bioactivity [1]. It has been also found that the high surface area and pore volume of sol-gel derived bioactive glasses can enhance the generation of hydroxyapatite on the surface of bioactive glass, in this context mesoporous bioactive glasses (MBGs) are being developed because of their high specific surface area and ordered pore structure which can be used for the loading and delivery of biomolecules [2]. In this work, mesoporous bioactive glass nanoparticles incorporating biologically active ions are synthesized in an aqueous solution by soft templating process. The structure and morphology of these nanoparticles will be characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). Multipoint Brumarer-Emmett-Teller (BET) N2 absorption technique is used to determine the surface area, the pore size distribution and the pore volume. The in vitro bioactivity analysis of these new mesoporous bioactive glass nanoparticles is performed in modified simulated body fluid (SBF) for 1, 3, 7, 14, 21 and 28 days. Furthermore, the drug delivery property of these nanoparticles will be evaluated in the context of intended applications in bone regeneration.

[1] Q. Z. Chen, et al., 45S5 Bioglass®-derived glass–ceramic scaffolds for bone tissue engineering, Biomaterials 27 (11), (2006) 2414-2425.

[2] J. Hum, et al., Mesoporous Bioactive Glass-Based Controlled Release Systems, Chapter 5 in: Inorganic Controlled Release Technology Materials and Concepts for Advanced Drug Formulation, Editor(s): Xiang Zhang and Mark Cresswell, Elsevier (2016), pp. 139–159.